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Pattern formation within phenotype-structured chemotactic populations
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Reducing phenotype-structured partial differential equations models of cancer evolution to systems of ordinary differential equations: a generalised moment dynamics approach
Chiara Villa, Philip K. Maini, Alexander P. Browning, Adrianne L. Jenner, Sara Hamis and Tyler Cassidy Journal of Mathematical Biology 91(2) (2025) https://doi.org/10.1007/s00285-025-02246-5
Mathematical modelling of cancer cell evolution and plasticity
Chloé Colson, Frederick JH. Whiting, Ann-Marie Baker and Trevor A. Graham Current Opinion in Cell Biology 95 102558 (2025) https://doi.org/10.1016/j.ceb.2025.102558
Identifiability of phenotypic adaptation from low-cell-count experiments and a stochastic model
Alexander P. Browning, Rebecca M. Crossley, Chiara Villa, Philip K. Maini, Adrianne L. Jenner, Tyler Cassidy, Sara Hamis and Guillermo Lorenzo PLOS Computational Biology 21(6) e1013202 (2025) https://doi.org/10.1371/journal.pcbi.1013202
The interplay between evolutionary and immunological dynamics regulates virus variant emergence and competition
Anass Bouchnita, Shraddha Ramdas Bandekar, Kaiming Bi, Behzad Djafari Rouhani, Spencer J. Fox and Juan A. Garcia Mathematical Modelling of Natural Phenomena 20 14 (2025) https://doi.org/10.1051/mmnp/2025006
The Impact of T-cell Exhaustion Dynamics on Tumour–Immune Interactions and Tumour Growth
Optimal control in reducing side effects during and after chemotherapy of solid tumors
Zeinab Joorsara, Seyed Mohammad Hosseini and Sakine Esmaili Mathematical Methods in the Applied Sciences 47(11) 8857 (2024) https://doi.org/10.1002/mma.10049
Sara Hamis, Alexander P Browning, Adrianne L Jenner, Chiara Villa, Philip K Maini and Tyler Cassidy (2024) https://doi.org/10.1101/2024.08.14.607616
Phenotype-structured model of intra-clonal heterogeneity and drug resistance in multiple myeloma
Ribonucleotide reductase regulatory subunit M2 drives glioblastoma TMZ resistance through modulation of dNTP production
Ella N. Perrault, Jack M. Shireman, Eunus S. Ali, Peiyu Lin, Isabelle Preddy, Cheol Park, Shreya Budhiraja, Shivani Baisiwala, Karan Dixit, C. David James, Dieter H Heiland, Issam Ben-Sahra, Sebastian Pott, Anindita Basu, Jason Miska and Atique U. Ahmed Science Advances 9(20) (2023) https://doi.org/10.1126/sciadv.ade7236
Spatio-temporal modelling of phenotypic heterogeneity in tumour tissues and its impact on radiotherapy treatment
Discrete and continuum models for the coevolutionary dynamics between CD8+ cytotoxic T lymphocytes and tumour cells
Luís Almeida, Chloe Audebert, Emma Leschiera and Tommaso Lorenzi Mathematical Medicine and Biology: A Journal of the IMA 40(2) 141 (2023) https://doi.org/10.1093/imammb/dqac017
Optimal chemotherapy counteracts cancer adaptive resistance in a cell-based, spatially-extended, evolutionary model
Bivalent chromatin as a therapeutic target in cancer: An in silico predictive approach for combining epigenetic drugs
Tomás Alarcón, Josep Sardanyés, Antoni Guillamon, Javier A. Menendez and Ilya Ioshikhes PLOS Computational Biology 17(6) e1008408 (2021) https://doi.org/10.1371/journal.pcbi.1008408
Phenotypic variation modulates the growth dynamics and response to radiotherapy of solid tumours under normoxia and hypoxia