| Issue |
Math. Model. Nat. Phenom.
Volume 4, Number 4, 2009
Morphogenesis
|
|
|---|---|---|
| Page(s) | 103 - 117 | |
| DOI | https://doi.org/10.1051/mmnp/20094403 | |
| Published online | 11 July 2009 | |
Multi-scale Modelling for Threshold Dependent Differentiation
1
Department of Mathematics, University of
California, Irvine, USA
2
Center for Mathematical and Computational Biology, University of
California, Irvine, USA
3
Department of Biological Chemistry, University of
California, Irvine, USA
Corresponding author: acai@uci.edu
The maintenance of a stable stem cell population in the epidermis is important for robust regeneration of the stratified epithelium. The population size is usually regulated by cell secreted extracellular signalling molecules as well as intracellular molecules. In this paper, a simple model incorporating both levels of regulation is developed to examine the balance between growth and differentiation for the stem cell population. In particular, the dynamics of a known differentiation regulator c-Myc, its threshold dependent differentiation, and feedback regulation on maintaining a stable stem cell population are investigated.
Mathematics Subject Classification: 92B05 / 35L60
Key words: cell division / cell differentiation / stem cells / threshold / cell population balance model / c-Myc / epidermal development
© EDP Sciences, 2009
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