Math. Model. Nat. Phenom.
Volume 5, Number 3, 2010Mathematical modeling in the medical sciences
|Page(s)||115 - 133|
|Published online||28 April 2010|
Weighted Elastic Net Model for Mass Spectrometry Imaging Processing
Department of Mathematical Science, Middle Tennessee State
Murfreesboro, Tennessee, USA
* Corresponding author. E-mail:
In proteomics study, Imaging Mass Spectrometry (IMS) is an emerging and very promising new technique for protein analysis from intact biological tissues. Though it has shown great potential and is very promising for rapid mapping of protein localization and the detection of sizeable differences in protein expression, challenges remain in data processing due to the difficulty of high dimensionality and the fact that the number of input variables in prediction model is significantly larger than the number of observations. To obtain a complete overview of IMS data and find trace features based on both spectral and spatial patterns, one faces a global optimization problem. In this paper, we propose a weighted elastic net (WEN) model based on IMS data processing needs of using both the spectral and spatial information for biomarker selection and classification. Properties including variable selection accuracy of the WEN model are discussed. Experimental IMS data analysis results show that such a model not only reduces the number of side features but also helps new biomarkers discovery.
Mathematics Subject Classification: 62J05 / 62J07 / 62H35 / 62P10
Key words: biomarker discovery / weighted elastic-net / mass spectrometry imaging / penalized regression / variable selection
© EDP Sciences, 2010
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