Issue |
Math. Model. Nat. Phenom.
Volume 6, Number 7, 2011
Mathematical modeling in biomedical applications
|
|
---|---|---|
Page(s) | 2 - 12 | |
DOI | https://doi.org/10.1051/mmnp/20116701 | |
Published online | 15 June 2011 |
Application of Hybrid Models to Blood Cell Production in the Bone Marrow
1
Institute of Mechanical Engineering Problems,
199178
Saint Petersburg,
Russia
2
Institut Camille Jordan, Université Lyon 1, UMR 5208
CNRS
69622
Villeurbanne,
France
3 INRIA Rhône-Alpes, Team-project “Dracula”
⋆ Corresponding author. E-mail: volpert@math.univ-lyon1.fr
A hybrid model of red blood cell production, where cells are considered as discrete objects while intra-cellular proteins and extra-cellular biochemical substances are described with continuous models, is proposed. Spatial organization and regulation of red blood cell production (erythropoiesis) are investigated. Normal erythropoiesis is simulated in two dimensions, and the influence on the output of the model of some parameters involved in cell fate (differentiation, self-renewal, and death by apoptosis) is studied.
Mathematics Subject Classification: 92C37
Key words: hybrid models / erythropoiesis / regulatory mechanisms
© EDP Sciences, 2011
Current usage metrics show cumulative count of Article Views (full-text article views including HTML views, PDF and ePub downloads, according to the available data) and Abstracts Views on Vision4Press platform.
Data correspond to usage on the plateform after 2015. The current usage metrics is available 48-96 hours after online publication and is updated daily on week days.
Initial download of the metrics may take a while.