Math. Model. Nat. Phenom.
Volume 6, Number 7, 2011Mathematical modeling in biomedical applications
|Page(s)||2 - 12|
|Published online||15 June 2011|
Application of Hybrid Models to Blood Cell Production in the Bone Marrow
Institute of Mechanical Engineering Problems,
2 Institut Camille Jordan, Université Lyon 1, UMR 5208 CNRS 69622 Villeurbanne, France
3 INRIA Rhône-Alpes, Team-project “Dracula”
⋆ Corresponding author. E-mail: firstname.lastname@example.org
A hybrid model of red blood cell production, where cells are considered as discrete objects while intra-cellular proteins and extra-cellular biochemical substances are described with continuous models, is proposed. Spatial organization and regulation of red blood cell production (erythropoiesis) are investigated. Normal erythropoiesis is simulated in two dimensions, and the influence on the output of the model of some parameters involved in cell fate (differentiation, self-renewal, and death by apoptosis) is studied.
Mathematics Subject Classification: 92C37
Key words: hybrid models / erythropoiesis / regulatory mechanisms
© EDP Sciences, 2011
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