| Issue |
Math. Model. Nat. Phenom.
Volume 10, Number 1, 2015
Hybrid models
|
|
|---|---|---|
| Page(s) | 48 - 63 | |
| DOI | https://doi.org/10.1051/mmnp/201510103 | |
| Published online | 13 February 2015 | |
Hybrid Models in Erythropoiesis and in Megakaryopoiesis
1 Institut Camille Jordan, UMR 5208
CNRS, University Lyon 1, 69622
Villeurbanne,
France
2 Faculté de Médecine Laennec, UMR 5558
CNRS, University Lyon 1, 69003
Lyon,
France
⋆
Corresponding author. E-mail: eymard@math.univ-lyon1.fr
Hematopoiesis is a complex process which results in production of erythrocytes, platelets and white blood cells from pluripotent stem cells located in the bone marrow. We will present hybrid models of hematopoiesis and will use them to study the lineage choice of bipotent erythro-megakaryocytic progenitors and erythroid lineage of hematopoiesis. Biological cells will be considered as individual objects, intracellular regulatory networks will be described with ordinary differential equations and biochemical substances in the extracellular matrix with partial differential equations.
Mathematics Subject Classification: 92C30 / 35K57 / 70F99
Key words: hybrid models / cell populations / intracellular regulation / hematopoiesis
© EDP Sciences, 2015
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