Math. Model. Nat. Phenom.
Volume 15, 2020
|Number of page(s)||27|
|Published online||24 September 2020|
Effects of delayed immune-activation in the dynamics of tumor-immune interactions
Department of Mathematics, Indian Institute of Engineering Science and Technology,
West Bengal, India.
* Corresponding author. firstname.lastname@example.org
Accepted: 26 January 2020
This article presents the impact of distributed and discrete delays that emerge in the formulation of a mathematical model of the human immunological system describing the interactions of effector cells (ECs), tumor cells (TCs) and helper T-cells (HTCs). We investigate the stability of equilibria and the commencement of sustained oscillations after Hopf-bifurcation. Moreover, based on the center manifold theorem and normal form theory, the expression for direction and stability of Hopf-bifurcation occurring at tumor presence equilibrium point of the system has been derived explicitly. The effect of distributed delay involved in immune-activation on the system dynamics of the tumor is demonstrated. Numerical simulations are also illustrated for elucidating the change of dynamic behavior by varying system parameters.
Mathematics Subject Classification: 97M60 / 37C75 / 65P30
Key words: Tumor-immune system interactions / delay differential equations / immune-activation distributed delay / Hopf-bifurcation
© The authors. Published by EDP Sciences, 2020
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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