Math. Model. Nat. Phenom.
Volume 16, 2021
|Number of page(s)||13|
|Published online||08 February 2021|
Spatiotemporal dynamics of a fractional model for hepatitis B virus infection with cellular immunity
Laboratory of Analysis, Modeling and Simulation (LAMS), Faculty of Sciences Ben M’sik, Hassan II University of Casablanca,
P.O Box 7955 Sidi Othman,
2 Laboratory of Mathematics and Applications (LMA), École Normale Supérieure, Hassan II University of Casablanca, Casablanca, Morocco.
3 Centre Régional des Métiers de l’Education et de la Formation (CRMEF), 20340 Derb Ghalef, Casablanca, Morocco.
* Corresponding author: email@example.com
Accepted: 19 December 2020
In this paper, we propose and investigate a fractional diffusive model for hepatitis B virus (HBV) infection with capsids and immune response presented by cytotoxic T lymphocyte (CTL) cells. We derive the conditions for global asymptotic stability of the steady states of the model in terms of the basic reproduction number R0 and the immune response reproduction number R1. By constructing appropriate Lyapunov functionals, it is shown that the infection-free equilibrium is globally asymptotically stable when R0 ≤ 1, the immune-free infection equilibrium is globally asymptotically stable when R1 ≤ 1 < R0 and the infection equilibrium with CTL immune response is globally asymptotically stable when R1 > 1. Numerical simulations are performed to illustrate the analytical results.
Mathematics Subject Classification: 26A33 / 37B25 / 37N25 / 92D30
Key words: HBV infection / diffusion / fractional derivative / global stability
© The authors. Published by EDP Sciences, 2021
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